Empirical evidence proves that agricultural research and development expenditure, and researchers attract high returns though the investments have long gestation periods. Nonetheless, Sub-Saharan Africa invests meagerly in agricultural research and development, and researchers. This study explores the impacts of agricultural research and development expenditures, and researchers on food security in the region and across the sub-regions. The study applies Bootstrapped linear squared dummy variable due to its capacity to handle heterogeneity and missing observations and two-step system generalized method of moments techniques to analyze the data on 24 sub-Saharan African countries over the period 2000–2016. Data on measures of food security, food production per capita, and food price index are obtained from Food and Agriculture Organization stat, data on population growth is sourced from World Development Indicators, and data on investments in agricultural innovations are extracted from International Food Policy Research Institute. Our findings show that investments in agricultural innovation substantially increase food security through food productivity growth. The full-time equivalent of agricultural researchers’ hours is more impactful on food security than agricultural research and development spending. The findings also reveal that the investments are more effective in enhancing food security in Eastern, Southern, and Western African sub-regions while they instead exacerbate the problem of food insecurity in Central Africa. The policy implications are that adequate resources should be channeled into proper agricultural research and development to introduce new crop varieties or significantly improved crops, etc. Moreover, there should be coordination between large and small countries in investments in order for the countries to benefit from the economies of scale.